Current Research
Our main questions are:
- How do trypanosomes 'listen' to each other to enable their developmental progression to stumpy forms in the bloodstream [read more in section I]
- How do trypanosomes know when to differentiate to the tsetse fly form: what molecules regulate the initiation of differentiation? [read more in section II]
- What prepares the trypanosome for uptake, survival and differentiation in the tsetse fly? [read more in section II]
- What governs the changes in the parasite during differentiation: which genes are regulated and how are they controlled? [read more in section III]
- Once differentiation is complete, how is the differentiated state maintained? [read more in section IV]
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