Matthews Lab Publications

2017|2016|2015|2014|2013| 2012| 2011|2010|2009|2008|2007 | 2006 | 2005 | 2004 | 2003 | Older

 

2017

 

 

 

Richard McCulloch, Christina A. Cobbold, Luisa Figueiredo, Andrew Jackson, Liam J. Morrison, Monica R. Mugnier, Nina Papavasiliou, Achim Schnaufer and Keith Matthews (2017).

Emerging challenges in understanding trypanosome antigenic variation

Emerging Topics in Life Sciences, in press.

 

Eleanor Silvester, Julie Young, Al Ivens and Keith R. Matthews (2017)

Interspecies quorum-sensing in co-infections can manipulate trypanosome transmission potential

Nature Microbiology, doi: 10.1038/s41564-017-0014-5

 

Steven Kelly, Al Ivens, G. Adam Mott, Ellis O’Neill, David Emms, Olivia Macleod, Paul Voorheis, Jacqueline Matthews, Keith R. Matthews* and Mark Carrington* (2017)
(* joint corresponding authors).


An alternative strategy for trypanosome survival in the mammalian bloodstream revealed through genome and transcriptome analysis of the ubiquitous bovine parasite Trypanosoma (Megatrypanum) theileri.

Genome Biology and Evolution, 9 (8) 2093-2109

Read the article here

 

Eleanor Silvester, Kirsty R. McWilliam and Keith R. Matthews (2017)

The cytological events and molecular control of life cycle development 
of Trypanosoma brucei in the mammalian  bloodstream.

Pathogens6(3), 29; doi:10.3390/pathogens6030029

 

Eva Rico, Alasdair Ivens, Lucy Glover, David Horn and Keith Matthews (2017)

Genome-wide RNAi selection identifies a regulator of transmission stage-enriched gene families and cell-type differentiation in Trypanosoma brucei

PLOS Pathogens 13(3):e1006279. doi: 10.1371/journal.ppat.100627

 

Kathrin Ulrich, Caroline Finkenzeller, Sabine Merker, Federico Rojas, Keith Matthews, Thomas Ruppert, and R. Luise Krauth-Siegel (2017)

Stress-induced Protein S-Glutathionylation and S-Trypanothionylation in African Trypanosomes – a Quantitative Redox Proteome and Thiol Analysis

Antioxidants and Redox Signalingdoi: 10.1089/ars.2016.6947.

 

2016

 

Jurgen R. Haanstra, Albert Gerding, Amalia M. Dolga, Freek J. H. Sorgdrager, Manon Buist- Homan, Francois du Toit, Klaas Nico Faber, Hermann-Georg Holzhutter, Balasz Szöõr, Keith Matthews, Jacky L. Snoep, Hans V. Westerhoff and Barbara M. Bakker (2016

Targeting pathogen metabolism without collateral damage to the host

Scientific Reports 13;7:40406. doi: 10.1038/srep40406.

 

Alan H. Fairlamb, Neil A. R. Gow, Keith R. Matthews* and Andrew P. Waters (2016)

(*Keith R. Matthews Corresponding author)

Drug resistance in eukaryotic microorganisms.

Nature Microbiology DOI: 10.1038/NMICROBIOL.2016.92 (PDF)

 

Enoch Antwi; Jurgen Haanstra; Gowthaman Ramasamy; Bryan Jensen; Dorothea Droll; Federico Rojas; Igor Minia; Monica Terrao; Clémentine Mercé; Keith R. Matthews; Peter Myler; Marilyn Parsons; Christine Clayton (2016)

Integrative analysis of the Trypanosoma brucei gene expression cascade predicts differential regulation of mRNA processing and unusual control of ribosomal protein expression.

BMC Genomics (in press)

 

2015

Maria Rosa Domingo Sananes, Balazs Szoor, Michael A.J. Ferguson, Michael Urbaniak and Keith R. Matthews (2015)

Molecular control of irreversible bistability during trypanosome developmental commitment

Journal of Cell Biology 211(2):455-68. doi: 10.1083/jcb.201506114.

 

Melanie Bühlmann, Pegine Walrad, Eva Rico Vidal, Alasdair Ivens, Paul Capewell, Arunasalam Naguleswaran, Isabel Roditi, and Keith R. Matthews (2015)

NMD3 regulates both mRNA and rRNA nuclear export in African trypanosomes via an XPOI-linked pathway

Nucleic Acids Research 19;43(9):4491-504.

 

Keith R Matthews, Richard McCulloch and Liam Morrison (2015)

The within host dynamics of African trypanosome infections

Philosophical Tranactions of the Royal Society (B) 19;370(1675).

 

Binny M Mony and Keith R. Matthews (2015)

Assembling the components of the quorum sensing pathway in African trypanosomes

Molecular Microbiology 96(2):220-32.

 

Keith R. Matthews (2015)

25 years of African trypanosome research: From description to molecular dissection and new drug discovery

Mol Biochem Parasitol. pii: S0166-6851(15)00010-9. doi: 10.1016/j.molbiopara.2015.01.006. [Epub ahead of print]

 

2014

 

Waters A, LoVerde P, Matthews K, Parsons M, Ginger M.(2014)

35 years of Molecular and Biochemical Parasitology (Editorial)

Mol Biochem Parasitol. Jul;195(2):75-6.

 

Abeer Fadda, Mark Ryten, Dorothea Droll, Federico Rojas, Valentin Färber, Jurgen R. Haanstra, Clemetine Merce, Barbara M. Bakker, Keith Matthews and Christine Clayton (2014)

Transcriptome-wide analysis of trypanosome mRNA decay reveals complex degradation kinetics and suggests a role for co-transcriptional degradation in determining mRNA levels

Molecular Microbiology, 2014; 94(2):307-26.

 

Achcar F, Fadda A, Haanstra JR, Kerkhoven EJ, Kim DH, Leroux AE, Papamarkou T, Rojas F, Bakker BM, Barrett MP, Clayton C, Girolami M, Krauth-Siegel RL, Matthews KR, Breitling R.(2014)

The silicon trypanosome: a test case of iterative model extension in systems biology.

Adv Microb Physiol. 2014;64:115-43.

 

Paula MacGregor, Alasdair Ivens, Steven Shave, Iain Collie, David Gray, Manfred Auer
 and Keith R. Matthews
(2014)

High throughput chemical screening for anti-virulence developmental phenotypes in Trypanosoma brucei.

Eukaryotic Cell 13(3):412-26

 

Binny M. Mony*; Paula MacGregor*; Alasdair Ivens, Federico Rojas, Andrew Cowton, Julie Young, David Horn and Keith R. Matthews (2013)

Genome wide dissection of the quorum sensing signalling pathway in Trypanosoma brucei

Nature doi:10.1038/nature12864

 

2013

 

Rico, E.; Rojas, F.; Mony, B.M; Szöõr, B.; MacGregor, P. and Keith R. Matthews (2013)

Bloodstream form pre-adaptation to the tsetse fly in Trypanosoma brucei.

Frontiers in Cellular and Infection Microbiology 3:78. doi: 10.3389/fcimb.2013.00078.

(read the article here)

 

Balázs Szöõr , Naomi Dyer, Irene Ruberto, Alvaro Acosta- Serrano and Keith R. Matthews (2013)

Independent pathways can transduce the life-cycle differentiation signal in Trypanosoma brucei

PLoS Pathogens 10.1371/journal.ppat.1003689

 

Balázs Szöõr and Keith R. Matthews (2013)

Protein phosphatases in Trypanosome growth and development,

In: Doerig, C., Späth, G., Wiese, M. (eds.) Protein Phosphorylation in Parasites: Novel Targets for
Antiparasitic Intervention, Wiley-Blackwell, pp. 155-177.

 

Paula MacGregor, Federico Rojas, Samuel Dean and Keith R. Matthews (2013)

Stable transformation of pleomorphic bloodstream form Trypanosoma brucei

Molecular and Biochemical Parasitology 190(2):60-2.

 

Paul Capewell, Stephanie Monk, Alasdair Ivens, Paula MacGregor, Katelyn Fenn, Pegine Walrad, Frederic Bringaud , Terry K. Smith, and Keith R. Matthews (2013)

Regulation of Trypanosoma brucei total and polysomal mRNA during development within its mammalian host

PLoS One 8(6):e67069.

 

Darren Creek, Brunda Nijagal, Dong-Hyun Kim, Federico Rojas, Keith R. Matthews and Michael Barrett (2013)

Metabolomics guides rational development of a simplified cell culture medium for drug screening against Trypanosoma brucei

Antimicrob Agents Chemother. 2013 Apr 9. [Epub ahead of print]

 

Monk, S., Simmonds, P. and Matthews, K. R. (2013)

A short bifunctional element operates to positively or negatively regulate

ESAG9 expression in different developmental forms of Trypanosoma brucei.

J Cell Sci. 2013 Mar 22. [Epub ahead of print]

 

2012

 

Irene Ruberto, Balazs Szoor, Rachel Clark and Keith R. Matthews (2012)

Investigating mammalian tyrosine phosphatase inhibitors as potential “piggyback” leads to target Trypanosoma brucei transmission

Chemical Biology & Drug Design. 81(2):291-301

 

MacGregor, P. and Keith R. Matthews (2012)

Identification of the regulatory elements controlling the transmission-stage specific gene expression of PAD1 in Trypanosoma brucei.

Nucleic Acids Research. 40(16):7705-17. Epub 2012 Jun 7.

 

MacGregor, P.; Szoor, B.; Savill, N. and Keith R. Matthews (2012)

Trypanosome Immune evasion, chronicity and transmission: an elegant balancing act

Nature Reviews Microbiology doi:10.1038/nrmicro2779

 

Little, TJ, Allen, JE, Babayan, SA, Matthews, KR, & N. Colegrave (2012)

Harnessing evolutionary biology to combat infectious disease.

Nature Medicine, 18: 217-220.

 

2011

Walrad, Pegine; Capewell, Paul; Fenn, Katelyn and Keith R. Matthews (2011)

The post-transcriptional trans-acting regulator, TbZFP3, co-ordinates transmission-stage enriched mRNAs in Trypanosoma brucei.

Nucleic Acids Research PMID: 22140102

G. Adam Mott, Raymond Wilson, Anuruddika Fernando, Ailie Robinson, Paula
MacGregor, David Kennedy, Dick Schaap, Jacqueline B. Matthews and Keith R. Matthews

Targeting cattle-borne zoonoses and cattle pathogens using a novel trypanosomatid
based delivery system.

PLoS Pathogens, 7 (10): e1002340.

 

MacGregor P, Savill NJ, Hall D, Matthews KR.

Transmission stages dominate trypanosome within-host dynamics during chronic infections.

Cell Host Microbe. 2011 Apr 21;9(4):310-8.

Matthews, K. R.

Controlling and co-ordinating development in vector-transmitted parasites

Science. Vol. 331 no. 6021 pp. 1149-1153

 

Pollit, L.C.; MacGregor, P.; Matthews, K. R. and Reece, S.

Malaria and trypanosome transmission: different parasites, same rules?
Trends in Parasitology, Feb 21. [Epub ahead of print]

Natesan SK, Black A, Matthews KR, Mottram JC, Field MC.

Trypanosoma brucei brucei: Endocytic recycling is important for mouse infectivity.
Exp Parasitol. 2011 Jan 20. [Epub ahead of print]

2010

Barnwell E, Van Deursen F, Jeacock L, Smith K, Maizels R, Acosta-Serano A and Matthews KR

Developmental regulation and extracellular release of a VSG expression site-associated gene product from Trypanosoma brucei bloodstream
forms

Journal of Cell Science , Oct 1;123(Pt 19):3401-11.

Chan K, Matthews KR and Erfeld, K.

Functional characterisation and drug target validation of a mitotic Kinesin-13 in Trypanosoma brucei

PLoS Pathogens, 19;6(8). pii: e1001050.

Szoor B, Ruberto I, Burchmore R and Matthews, K.R.

A novel phosphatase cascade regulates differentiation in Trypanosoma brucei via a glycosomal signalling pathway

Genes and Development, 24(12):1306-16.

MacGregor, P and Matthews, K.R.

New discoveries in the transmission biology of sleeping sickness parasites: applying the basics

Journal of Molecular Medicine , 88(9):865-71. Epub 2010 Jun 5.

Barbara M. Bakker, R. Luise Krauth-Siegel, Christine Clayton, Keith Matthews,
Mark Girolami, Hans V. Westerhoff, Paul A. M. Michels, Rainer Breitling, Michael
P. Barrett

The Silicon trypanosome

Parasitology, May 6:1-9. [Epub ahead of print]

Droll D, Archer S, Fenn K, Delhi P, Matthews K, Clayton C.

The trypanosome Pumilio-domain protein PUF7 associates with a nuclear cyclophilin and is involved in ribosomal RNA maturation.

FEBS Lett. 2010 Feb 11. [Epub ahead of print]

2009

Natesan SK, Peacock L, Leung KF, Matthews KR, Gibson W, Field MC.

The trypanosome Rab-related proteins RabX1 and RabX2 play no role in intracellular trafficking but may be involved in fly infectivity.

PLoS One. 2009 Sep 29;4(9):e7217.

Kabani, S.; Watefall, M. and Matthews K.R.

Cell-cycle synchronisation of bloodstream forms of Trypanosoma brucei using Vybrant DyeCycle Violet-based sorting.

Mol Biochem Parasitol. 2010 Jan;169(1):59-62.

Kabani, S,; Fenn, K.; Ross, A.; Ivens, A.; Smith, T.K.; Ghazal, P. and Matthews K. R. (2009)

Genome-wide expression profiling of in vivo-derived bloodstream parasite stages and dynamic analysis of mRNA alterations during synchronous differentiation in Trypanosoma brucei.

BMC Genomics. 2009 Sep 11;10:427.

 

Dean, S.; Marchetti, R.; Kirk, K. and Matthews K.R. (2009)

A surface transporter family conveys the trypanosome differentiation signal

Nature 459: 213-217

 

Walrad, P.; Paterou, A.; Acosta-Serrano, A. and Matthews, K.R. (2009)

Differential trypanosome surface coat regulation by a CCCH protein that co-associates with procyclin mRNA cis-elements

PLoS Pathogens, Feb 5(2):e1000317.

2008

Matthews, J.B.; Johnson, D.R.; Lazari, O.; Craig, O. and Matthews, K. R. (2008)

Identification of a LIM domain-containing gene in the Cyathostominae
Veterinary Parasitology 154(1-2):82-93.

MacGregor, P and Matthews, K.R. (2008)

Modelling trypanosome chronicity: VSG dynasties and parasite density.

Trends in Parasitology. 24(1):1-4.[INVITED ARTCLE]

 

2007

Dean, S.D and Matthews, K.R. (2007)

Restless gossamers: antibody clearance by hydrodynamic flow forces generated at the surface of motile trypanosome parasites. [INVITED "PREVIEW']

'Cell'- Host and Microbe.2(5):279-28

Brenchley, R.; Tariq, H.; McElhinney, H.; Szoor, B.; Stevens, R.; Matthews, K.R. and Tabernero L. (2007)

The TriTryp Phosphatome: analysis of the protein phosphatase catalytic domains

BMC Genomics. 8(1):434

Fenn, K and Matthews, K.R. (2007)

The Cellular Biology of Trypansoma brucei development. [INVITED "REVIEW"]

Current Opinion in Microbiology. Nov 8; [Epub ahead of print].

Natesan, S.K.; Peacock, L.; Matthews,  KR.; Gibson, W. and Field, MC. (2007)

Activation of the endocytic system as a component of adaptation to the mammalian host in the African trypanosome.

Eukaryotic Cell: 6(11):2029-37.

Spoerri, I.; Chadwick, R.; Kunz-Renggli, C.; Matthews, K.R.; Roditi, I. and Burkard, G. (2007)

Role of the stage-regulated nucleoside transporter NT10 in differentiation and adenosine uptake in Trypanosoma brucei. Molecular and Biochemical Parasitology. 154(1):110-4.

Hendriks, E. and Matthews, K.R. (2007)

Post transcriptional control of gene expression in African trypanosomes. Book Chapter in “Trypanosomes — After the Genome”.Chapter 7. pp209-237. Horizon Press.

 

2006

Szöőr, B; Wilson, J., McElhinney, H.; Tabernero, L. and Matthews KR (2006)

Protein tyrosine phosphatase TbPTP1: a molecular switch controlling life cycle differentiation in Trypanosoma brucei. Journal of Cell Biology. 175(2):293-303.

Paterou A, Walrad P, Craddy P, Fenn K, Matthews K. (2006)

Identification and stage-specific association with the translational apparatus of TbZFP3, a ccch protein that promotes trypanosome life cycle development. J Biol Chem. 281(51):39002-13

Matthew Mayho, Katelyn Fenn, Paul Craddy, Susan Crosthwaite and Matthews, K. (2006)

Post-transcriptional control of nuclear-encoded cytochrome oxidase subunits in Trypanosoma brucei: evidence for genome-wide conservation of life-cycle stage-specific regulatory elements. Nucleic Acids Research. 34(18):5312-24.

 
Subramaniam, C.; Veazey, P.; Redmond, S.; Hayes-Sinclair, J. Chambers, E.; Carrington, M.; Gull, K.; Matthews, K.R*.; Horn, D.*, Field, M.* (* joint corresponding authors) (2006)

A chromosome-wide analysis of gene function by RNAi in the African trypanosome. Eukaryotic Cell. 5: 1539-1549.

Christian J. Janzen , Frederick van Deursen, Huafang Shi, George, A. M. Cross, Keith, R.  Matthews and Elisabetta Ullu. (2006)

Expression site silencing and life-cycle progression appear normal in  Argonaute1-deficient Trypanosoma brucei. Mol Biochem parasitol. 149(1):102-7.

A.E. Gruszynski, F.J. van Deursen, students of the ‘Biology of Parasitism 2003’ course, K.R. Matthews, and J.D. Bangs. (2006).

Regulation of Surface Coat Exchange by Differentiating African Trypanosomes. Mol Biochem parasitol. 147(2):211-23.

2005

Alasdair C. Ivens, et al. (2005)

The genome of the kinetoplastid parasite, Leishmania major. Science 309(5733):436-42.

Matthews, K. R.  (2005)

‘Parasites revisited’ Book Review of The Trypanosomiases. Trends in Parasitology

Hendriks, E. and Matthews, K. R. (2005)

Disruption of the developmental programme of Trypanosoma brucei by genetic ablation of TbZFP1, a differentiation-enriched CCCH protein. Molecular Microbiology  57: 706-716.

Johnston CE, Bradley JE, Behnke JM, Matthews KR, Else KJ.

Isolates of Trichuris muris elicit different adaptive immune responses in their murine host. Parasite Immunol. 2005 27(3):69-78.

K. R. Matthews (2005)
The developmental cell biology of Trypanosoma brucei. Journal of Cell Science 118(Pt 2):283-90.

2004

Matthews. K.R., Melville, S. and Turner, CMR. (2004)

The application of genomic technology to combat scientific disease. Editorial preface to Parasitology special supplement.  Parasitology 128: S1-S2

J.R. Ellis, M. Sarkar, E.F. Hendriks, and K. R. Matthews (2004).

A novel ERK-like, CRK-like protein kinase that modulates growth in Trypanosoma brucei via an autoregulatory C-terminal extension. Molecular Microbiology 53: 1487-1500.

M. A. Sanchez, S. Drutman, M. van Ampting, K.R.  Matthews and S.M. Landfear.

A Novel Purine Nucleoside Transporter whose Expression is Upregulated in the Short Stumpy Form of the T. brucei Life Cycle. (2004). Molecular and Biochemical parasitology  136: 265-272.

Matthews, K.R.; Ellis, J and Paterou, A. (2004).

The molecular regulation of the trypanosome life cycle. Trends in Parasitology. 20(1):40-47.

2003

E. F. Hendriks, Abdul-Razak, A. and K. R. Matthews (2003).

tbCPSF30 depletion by RNAi disrupts polycistronic RNA processing in Trypanosoma brucei. Journal of Biological Chemistry. 278(29):26870-8.

van Deursen, F.J ; Francis, S and Matthews, K.R. (2003)

A reproducible protocol for analysis of the proteome of Trypanosoma brucei. Molecular and Biochemical Parasitology  128:107-110.

Key Earlier publications

Timms, M.; van Deursen, F.J; Hendriks, E. and Matthews, K.R. (2002)

Mitochondrial development during life-cycle differentiation of the African trypanosome: evidence for a kinetoplast-dependent differentiation control point. Molecular Biology of the Cell. 13: 3747-3759.

Hendriks, E.; Robinson, D.R. , Hinkins, M and Matthews, K.R. (2001).

A novel CCCH protein which modulates differentiation of Trypanosoma brucei to its procyclic form. EMBO J. 20:6700-6711.

Tasker, M. Timms, M., Hendriks, E. and Matthews K.R. (2001).

Mitochondrial cytochrome oxidase subunit VI of Trypanosoma brucei is imported without a cleaved leader sequence and is developmentally regulated at both RNA and protein levels. Molecular Microbiology 39:272-285.

Tasker, M.; Wilson, J., Sarkar, M., Hendriks, E. and Matthews K.R. (2000).

A novel selection scheme for differentiation defects demonstrates an essential role for the stumpy form in the life cycle of the African trypanosome. Molecular Biology of the Cell 11:1905-1917.

Bastin, P.; MacRae, T.; Frances, S.B.; Matthews, K.R. and Gull, K. (1999).

Flagellar Morphogenesis: protein targetting and assembly in the paraflagellar rod of trypanosomes. Molecular and Celluar Biology 19: 8191-8200.

Matthews, K.R. and Gull, K. (1997).

Commitment to differentiation and cell cycle re-entry are coincident but separable events in the transformation of African trypanosomes from their bloodstream to their insect form. Journal of Cell Science. 110: 2609-2618.

Matthews, K.R.; Sherwin, T. and Gull, K (1995).

Mitochondrial genome repositioning during the differentiation of the African trypanosome between life cycle forms is microtubule mediated. Journal of Cell Science 108: 2231-2239.

Matthews, K.R. and Gull, K. (1994).

Evidence for an interplay between cell cycle progression and the initiation of differentiation between life cycle forms in the African trypanosome. Journal of Cell Biology. 125: 1147-1156.

Matthews K.R.; Tschudi, C. and Ullu, E. (1994).

A common pyrimidine-rich motif governs trans-splicing and polyadenylation of tubulin polycistronic pre-mRNA in trypanosomes. Genes and Development. 8: 491-501.

Tschudi, C.; Matthews, K.R. and Ullu, E. (1993).

Temporal order of RNA processing reactions in trypanosomes: rapid trans splicing precedes polyadenylation of newly-synthesised tubulin transcripts. Molecular and Cellular Biology. 13: 720-725.